期刊简介
本刊是中国科学技术协会主管、中国病理生理学会主办、暨南大学承办的国家级综合性病理生理学高级学术刊物。杂志刊登有关病理生理学理论研究（包括实验研究和临床研究）方面的论著、专题综述、教学研究、科研仪器和药品评价介绍等，注重介绍疾病发病机制和临床病理生理学研究。适合医药院校教学科研人员、研究生、临床医务工作者和高年级医学生阅读。
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首页>中国病理生理杂志
- 杂志名称：中国病理生理杂志
- 主管单位：中国科学技术协会
- 主办单位：中国病理生理学会
- 国际刊号：1000-4718
- 国内刊号：44-1187/R
- 出版周期：月刊
期刊荣誉：2008和2011年分别被评为第一届和第二届中国精品科技期刊；2008～2011年连续4次荣获“百种中国杰出学术期刊”奖；2011年被评为RCCSE（武汉大学中国科学评价研究中心）中国权威期刊；2010年荣获广东省期刊评选最高奖——品牌期刊奖；2011年荣获广东省优秀科技期刊一等奖。期刊收录：万方收录(中), JST 日本科学技术振兴机构数据库(日), 北大核心期刊(中国人文社会科学核心期刊), CA 化学文摘(美), 上海图书馆馆藏, 维普收录(中), 统计源核心期刊(中国科技论文核心期刊), 知网收录(中), CSCD 中国科学引文数据库来源期刊(含扩展版), 国家图书馆馆藏
关键词：signal transduction pathway, protein kinase, central nervous system, body temperature
摘要：The primary action of corticotropin releasing hormone (CRH) is stimulation of the synthesis and release of adrenocorticotropic hormone and β-endorphin from the pituitary in response to stress. In addition, a number of studies indicate that CRH exerts other physiological actions within the central nervous system which are independent of the pituitary. These include increased body temperature and thermogenesis. However, the intracellular mechanism responsible for pyrogenic action of CRH is still unclear. The purpose of these studies was to determine whether or not cAMP was involved in the pyrogenic action of CRH in the rat. Intracerebroventricular (icv) microinjection of CRH (2.5 μg, 5.0 μg, 10 μg) caused increases in colonic temperature and hypothalamus cAMP level in conscious rats. The pyrogenic effects of CRH were abolished or markedly inhibited by prior injection (icv) of an adenylate cyclase inhibitor, 2，，3，-dideoxyadenosine (DDA, 30 μg) or an inhibitor of cAMP-dependent protein kinase, adenosine-3，，5，-(cyclic) monophosphorothionate (Rp-cAMPs, 15 μg). This is the first report demonstrating the pyrogenic effcet of centrally administration of CRH on the rat via the cAMP-mediated protein kinase signal transduction pathway.
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