期刊简介
本刊是中国科学技术协会主管、中国病理生理学会主办、暨南大学承办的国家级综合性病理生理学高级学术刊物。杂志刊登有关病理生理学理论研究（包括实验研究和临床研究）方面的论著、专题综述、教学研究、科研仪器和药品评价介绍等，注重介绍疾病发病机制和临床病理生理学研究。适合医药院校教学科研人员、研究生、临床医务工作者和高年级医学生阅读。
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首页>中国病理生理杂志
- 杂志名称：中国病理生理杂志
- 主管单位：中国科学技术协会
- 主办单位：中国病理生理学会
- 国际刊号：1000-4718
- 国内刊号：44-1187/R
- 出版周期：月刊
期刊荣誉：2008和2011年分别被评为第一届和第二届中国精品科技期刊；2008～2011年连续4次荣获“百种中国杰出学术期刊”奖；2011年被评为RCCSE（武汉大学中国科学评价研究中心）中国权威期刊；2010年荣获广东省期刊评选最高奖——品牌期刊奖；2011年荣获广东省优秀科技期刊一等奖。期刊收录：万方收录(中), JST 日本科学技术振兴机构数据库(日), 北大核心期刊(中国人文社会科学核心期刊), CA 化学文摘(美), 上海图书馆馆藏, 维普收录(中), 统计源核心期刊(中国科技论文核心期刊), 知网收录(中), CSCD 中国科学引文数据库来源期刊(含扩展版), 国家图书馆馆藏
关键词：New Zealand White Rabbits, animal model
摘要：To observe the effects of diabetogenic (high fat high sucrose, lacking choleserol) diet on atherogenesis in New Zealand white rabbits. Two groups of New Zealand white rabbits received regular rabbit chow (the normal control), or high fat high sucrose diet for 4 months. The levels of plasma total cholesterol, HDL cholesterol, triglycerides, insulin, and glucose were investigated, the areas of fatty streak of the aortae were measured after staining with Sodan IV, and the aortic, coronary specimens were observed with light and electron microscopies. The plasma glucose, triglycerides, and total cholesterol were increased significantly by high fat high sucrose feeding. At the end of 4 months, the early charateristics of atherosclerosis were present in the animals' vascular specimens. Our findings suggest that high fat high sucrose feeding can induce hyperglycemia, hypertriglyceridemia and atherosclerosis in New Zealand white rabbits, and this could be a potential animal model for studying the mechanisms of diabetes-accelerated atherosclerosis. This study raised a question: What is the mechanism by which high fat high sucrose feeding induces atherosclerosis?. The related hypothesis was given in this article.
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